Zeptol CR Dosage/Direction for Use

ZEPTOL CR is a controlled release formulation for oral administration. The distinct advantages are reduced peak plasma concentrations and reduced fluctuations in plasma concentration throughout the day. Therefore, ZEPTOL CR can be given twice daily. The tablet should not be chewed but swallowed wholly with little liquid during meal or after meal. 100-200 mg once or twice daily is the initiation dose. Carefully observe the response and give small increments of 200 mg/week until the best response is obtained which is usually at the range of 800-1200 mg per day (400 mg bid or 600 mg bid). In elderly, there is no specific reason for dosage adjustments in the absence of liver, kidney or heart disease. However, a smaller initiation dose is recommended. In children (age more than 5 years), the dose is 10-20 mg/kg body weight in 2 divided doses. The preparation is not recommended for children below 5 years. 400-600 mg per day and 600-1000 mg per day is the maximum recommended dose for children aged 5-10 years and 10-15 years, respectively.
For trigeminal neuralgia, the dose is variable and should be individualised on the basis of weight, age and reduction in pain. For majority of the patients, ZEPTOL CR doses of 600-800 mg are adequate for complete pain relief. ZEPTOL CR should be recommended ideally during acute stage and not for prophylaxis.